ERP biomarker program

What

An event-related potential, or ERP, is a response in EEG associated with a timed stimulus or task. At Alto, I built a program for collecting and analyzing these responses in clinical studies.

Why it mattered

A trial needs measurements that can be collected consistently across sites. We checked stimulus timing, EEG trigger alignment, signal quality, and analysis behavior on recordings from the actual system.

My role

Built the program across experimental design, acquisition, and analysis. The work included task selection, timing tests, preprocessing, artifact handling, ERP extraction, and validation. I worked with clinical, engineering, and drug-development teams, and partnered with technical solutions on site collection and quality-control tools.

Outcome

An EEG/ERP measure from the program was used as the primary pharmacodynamic endpoint in a Phase 2 trial. The ALTO-101 trial did not achieve statistical significance on its primary EEG or cognitive endpoints versus placebo, as reported in April 2026.

First author on the SOBP 2025 translational ERP poster and a named inventor on US 2025/0120957 A1. The linked sources describe the methods and results.